Neuroscience

Decision neuroscience

Mathematical modeling of learning and decision making and associated brain processes

Thalamo-cortical functional connectivity in schizophrenia and bipolar disorder

The thalamus is a highly connected subcortical structure that relays and integrates sensory and cortical information, which is critical for coherent and accurate perceptual awareness and cognition. Thalamic dysfunction is a classical finding in …

Increased default-mode variability is related to reduced task-performance and is evident in adults with ADHD

Insufficient suppression and connectivity of the default mode network (DMN) is a potential mediator of cognitive dysfunctions across various disorders, including attention deficit/hyperactivity disorder (ADHD). However, it remains unclear if …

Global brain connectivity alterations in patients with schizophrenia and bipolar spectrum disorders

BACKGROUND. The human brain is organized into functionally distinct modules of which interactions constitute the human functional connectome. Accumulating evidence has implicated perturbations in the patterns of brain connectivity across a range of …

Evidence Accumulation and Choice Maintenance Are Dissociated in Human Perceptual Decision Making

Perceptual decision making in monkeys relies on decision neurons, which accumulate evidence and maintain choices until a response is given. In humans, several brain regions have been proposed to accumulate evidence, but it is unknown if these regions …

The neural basis of risky choice with affective outcomes

Both normative and many descriptive theories of decision making under risk are based on the notion that outcomes are weighted by their probability, with subsequent maximization of the (subjective) expected outcome. Numerous investigations from …

Effects of PPP1R1B (DARPP-32) Polymorphism on Feedback-Related Brain Potentials Across the Life Span

Maximizing gains during probabilistic reinforcement learning requires the updating of choice - outcome expectations at the time when the feedback about a specific choice or action is given. Extant theories and evidence suggest that dopaminergic …

The importance of context. when relative relief renders pain pleasant

Context can influence the experience of any event. For instance, the thought that ``it could be worse'' can improve feelings towards a present misfortune. In this study we measured hedonic feelings, skin conductance, and brain activation patterns in …

Temporal characteristics of the influence of punishment on perceptual decision making in the human brain

Perceptual decision making is the process by which information from sensory systems is combined and used to influence our behavior. In addition to the sensory input, this process can be affected by other factors, such as reward and punishment for …

How expert advice influences decision making

People often use expert advice when making decisions in our society, but how we are influenced by this advice has yet to be understood. To address this, using functional magnetic resonance imaging, we provided expert and novice advice to participants …